Research progress in the treatment of sleep disorder in chronic fatigue syndrome with external therapy of Traditional Chinese Medicine / 国际中医中药杂志

Traditional Chinese Medicine (TCM) external therapy for sleep disorder of chronic fatigue syndrome (CFS) has good anti-fatigue effect and can improve sleep quality of patients. The treatment for sleep disorders of CFS with TCM external treatment mainly adopts acupuncture, moxibustion, massage, TCM bath, transcutaneous acupoint electrical stimulation and auricular point sticking, etc., or alone, or comprehensive application, or combined with oral Chinese materia medica. The appropriate treatment method can be selected according to the patients' condition and compliance, which reflects the unique advantages of TCM syndrome differentiation and treatment and the treatment according to people and time. The existing research still needs to further form a standardized and recognized diagnosis and treatment system, so as to better guide clinical popularization and application.

Clinical application and mechanism of moxibustion for chronic fatigue syndrome / 国际中医中药杂志

The treatment rules of point selection and treatment principles for treating chronic fatigue syndrome (CFS) can be divided into three categories: regulating and replenishing, invigorating original yang and regulating zang-fu organs. The mechanism of moxibustion includes improving gut microbiota imbalance, regulating immune cell imbalance and correcting endocrine dysfunction. The moxibustion methods include ginger-partitioned moxibustion, thunder-fire moxibustion, warm acupuncture, and governor moxibustion. Acupuncture points such as Shenque (RN8), Guanyuan (RN4), Qihai (RN6), Zusanli (ST36), Baihui (DU20), Yongquan (KI1) and back-shu points are often selected to exert anti-chronic fatigue effects.

The therapeutic effect of sports on relieving chronic fatigue / O efeito terapêutico dos esportes no alívio da fadiga crônica / El efecto terapéutico de los deportes para aliviar la fatiga crónica

ABSTRACT Introduction Chronic fatigue syndrome (CFS) is a group of long-term fatigue; the rest is difficult to achieve. At the same time, it is accompanied by corresponding physical dysfunction and psychological and mental symptoms. It is very meaningful to find exercise countermeasures to cope with chronic fatigue syndrome actively. Object This article analyzes the current students' CFS to realize the cognition of the disease. At the same time, it analyzes the effect of sports on the treatment of chronic fatigue to help students formulate related sports programs. Method The article conducts a related questionnaire survey and analysis of students and analyzes CFS and exercise status symptoms. Results Generally, students with CFS did not actively participate in sports and had poor physical fitness, especially muscle endurance and cardiopulmonary function. However, students who actively participate in sports training basically do not have CFS. Conclusion CFS students should strengthen physical exercise and improve the CFS situation through exercise. Level of evidence II; Therapeutic studies - investigation of treatment results.

RESUMO Introdução a síndrome da fadiga crônica (SFC) é um grupo de fadiga de longa duração; o descanso é difícil de conseguir. Ao mesmo tempo, é acompanhado por disfunção física correspondente e sintomas psicológicos e mentais. É muito significativo encontrar contramedidas de exercícios para lidar ativamente com a síndrome da fadiga crônica. Objetivo este artigo analisa o CFS de alunos atuais para a compreensão da doença. Ao mesmo tempo, analisa o efeito dos esportes no tratamento da fadiga crônica para ajudar os alunos a formular programas esportivos relacionados. Método o artigo conduz uma pesquisa de questionário relacionada e análise de alunos e analisa CFS e sintomas de status de exercício. Resultados Geralmente, os alunos com SFC não participavam ativamente de esportes e apresentavam má aptidão física, principalmente resistência muscular e função cardiopulmonar. Por outro lado, os alunos que participam ativamente do treinamento esportivo basicamente não possuem CFS. Conclusão os alunos do CFS devem fortalecer o exercício físico e melhorar a situação do CFS por meio do exercício. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.

RESUMEN Introducción El síndrome de fatiga crónica (SFC) es un grupo de fatiga a largo plazo; el descanso es difícil de conseguir. Al mismo tiempo, se acompaña de la correspondiente disfunción física y síntomas psicológicos y mentales. Es muy significativo encontrar contramedidas de ejercicio para hacer frente activamente al síndrome de fatiga crónica. Objeto Este artículo analiza el SFC de los estudiantes actuales para comprender la enfermedad. Al mismo tiempo, analiza el efecto del deporte en el tratamiento de la fatiga crónica para ayudar a los estudiantes a formular programas deportivos relacionados. Método El artículo lleva a cabo un cuestionario relacionado y un análisis de los estudiantes y analiza los síntomas del SFC y el estado del ejercicio. Resultados En general, los estudiantes con SFC no participaron activamente en deportes y tenían una mala condición física, especialmente la resistencia muscular y la función cardiopulmonar. Por otro lado, los estudiantes que participan activamente en el entrenamiento deportivo básicamente no tienen SFC. Conclusión Los estudiantes de CFS deben fortalecer el ejercicio físico y mejorar la situación de CFS a través del ejercicio. Nivel de evidencia II; Estudios terapéuticos: investigación de los resultados del tratamiento.

Sports medicine treatment based on relieving chronic fatigue and sub-health state / Tratamento da medicina do esporte relacionada ao alivio da fadiga crônica e saúde sub-ótima / Tratamiento de la medicina del deporte relacionada al alivio de la fatiga crónica y salud subóptima

ABSTRACT Introduction: Chronic fatigue syndrome (CFS), also known as chronic fatigue and immune dysfunction syndrome, has become a common disease in modern medicine. Objective: The paper analyzes the impact of exercise training on patients' quality of life with chronic fatigue syndrome. Methods: We conducted fatigue investigations on college students and analyzed the exercise ability of college students with chronic fatigue syndrome. We then compared the findings with healthy college students. In the process, we recorded the physiological indicators and satisfaction scores of the two groups of patients. Results: Muscle endurance and cardiopulmonary function-related exercise ability of the college students with chronic fatigue syndrome are significantly different. After completing the same exercise, the scores of personal exertions were higher. Conclusion: Appropriate and regular exercise can achieve ideal results in the treatment of chronic fatigue syndrome. In-depth research, popularization, and application by scholars is highly suggested. Level of evidence II; Therapeutic studies - investigation of treatment results.

RESUMO Introdução: A síndrome da fadiga crônica (SFC), também conhecida como fadiga crônica e síndrome de disfunção imunológica, tem se tornado uma doença comum para a medicina moderna. Objetivo: Este estudo analisa o impacto do treinamento de exercícios na qualidade de vida de pacientes com síndrome de fadiga crônica. Métodos: Conduzimos investigações sobre a fadiga em estudantes universitários e analisamos a habilidade para exercícios de estudantes universitários com síndrome de fadiga crônica. Durante o processo, registramos indicadores fisiológicos e escores de satisfação dos dois grupos de pacientes. Resultados: A resistência muscular e habilidade em praticar exercícios relacionados à função cardiopulmonar dos estudantes universitários com síndrome de fadiga crônica são significativamente diferentes. Após completar o mesmo exercício, os escores de esforço pessoal eram mais altos. Conclusão: Exercícios adequados e regulares podem atingir resultados ideais no tratamento da síndrome de fadiga crônica. Pesquisas aprofundadas, a popularização e a aplicação por parte de pesquisadores são altamente recomendadas. Nível de evidência II; Estudos terapêuticos - investigação de resultados de tratamento.

RESUMEN Introducción: La síndrome de la fatiga crónica (SFC), también conocida como fatiga crónica e inmunodeficiencia, se ha tornado una enfermedad común para la medicina moderna. Objetivo: Este estudio analiza el impacto del entrenamiento de ejercicios en la calidad de vida de pacientes con síndrome de fatiga crónica. Métodos: Conducimos investigaciones sobre la fatiga en estudiantes universitarios y analizamos la habilidad para ejercicios de estudiantes universitarios con síndrome de fatiga crónica. Durante el proceso, registramos indicadores fisiológicos y puntajes de satisfacción de los dos grupos de pacientes. Resultados: La resistencia muscular y habilidad en practicar ejercicios relacionados a la función cardiopulmonar de los estudiantes universitarios con síndrome de fatiga crónica son significativamente diferentes. Tras completar el mismo ejercicio, los puntajes de esfuerzo personal eran más altos. Conclusión: Ejercicios adecuados y regulares pueden atingir resultados ideales en el tratamiento de la síndrome de fatiga crónica. Investigaciones profundizadas, la popularización y la aplicación por los investigadores son altamente recomendadas. Nivel de evidencia II; Estudios terapéuticos - investigación de resultados de tratamiento.

Scientific physical training on the clinical recovery of chronic fatigue injury / Treino físico científico para a recuperação de lesões por fadiga crônica / Entrenamiento físico científico para la recuperación de lesiones por fatiga crónica

ABSTRACT Introduction: Chronic fatigue syndrome is also called chronic fatigue and immune dysfunction syndrome. This disease has now become a common disease in modern medicine. Objective: To explore and analyze the effect of exercise therapy on chronic fatigue syndrome. Methods: We selected 70 patients with chronic fatigue syndrome for the experiment. The exercise group performed gradual exercise, and the control group was inactive. Results: Appropriate and regular exercise can achieve ideal results in the treatment of chronic fatigue syndrome. Conclusion: Studying methods to prevent and recover from fatigue syndrome will help in understanding and focusing attention on the topic of fatigue, as well as being aware of the methods of self-prevention of fatigue syndrome. Level of evidence II; Therapeutic studies - investigation of treatment results.

RESUMO Introdução: A síndrome de fadiga crônica é também chamada de fadiga crônica e síndrome de disfunção imune. Esta doença tem se tornado comum na medicina moderna. Objetivo: Explorar e analisar o efeito da terapia por exercício na síndrome de fadiga crônica. Métodos: Selecionamos 70 pacientes com síndrome de fadiga crônica para o experimento. O grupo de exercício praticou exercícios moderados e o grupo de controle permaneceu inativo. Resultados: Exercícios adequados e regulares podem atingir resultados ideais no tratamento da síndrome de fadiga crônica. Conclusão: O estudo de métodos para prevenir e se recuperar da síndrome de fadiga crônica ajuda ao entender e ficar atento ao tema da fadiga, assim como reconhecer os métodos de autoprevenção da síndrome da fadiga. Nível de evidência II; Estudos terapêuticos - investigação de resultados de tratamento.

RESUMEN Introducción: El síndrome de fatiga crónica se llama también fatiga crónica y síndrome de disfunción inmune. Esta enfermedad se ha vuelto común en la medicina moderna. Objetivo: Explorar y analizar el efecto de la terapia por ejercicio en el síndrome de fatiga crónica. Métodos: Seleccionamos 70 pacientes con síndrome de fatiga crónica para el experimento. El grupo de ejercicios practicó ejercicios moderados y el grupo de control permaneció inactivo. Resultados: Ejercicios adecuados y regulares pueden atingir resultados ideales en el tratamiento del síndrome de fatiga crónica. Conclusión: El estudio de métodos para prevenir y recuperarse del síndrome de fatiga crónica ayuda a entender y estar atento al tema de la fatiga, así como reconocer los métodos de autoprevención del síndrome de fatiga. Nivel de evidencia II; Estudios terapéuticos - investigación de resultados de tratamiento.

Estudo Controlado das Alterações Hemodinâmicas Centrais de uma Sessão de Exercício Inspiratório com Diferentes Cargas na Insuficiência Cardíaca / Controlled Study of Central Hemodynamic Changes in Inspiratory Exercise with Different Loads in Heart Failure

Resumo Fundamento A fraqueza muscular inspiratória contribui para a intolerância ao exercício e diminuição da qualidade de vida dos pacientes com insuficiência cardíaca. Estudos com treinamento da musculatura inspiratória demonstram melhora da força muscular inspiratória, da capacidade funcional e da qualidade de vida. Porém, pouco se sabe sobre a resposta hemodinâmica central (RHC) durante o exercício inspiratório (EI). Objetivo Avaliar a RHC em uma única sessão de EI com diferentes cargas (placebo, 30 e 60%) na insuficiência cardíaca. Métodos Ensaio clínico randomizado placebo-controlado, em pacientes com insuficiência cardíaca com fração de ejeção reduzida, classe funcional II e III. Vinte pacientes, com idade de 65±11 anos, completaram uma sessão única de exercício inspiratório, em 3 ciclos de 15 minutos, com washout de 1 hora, envolvendo cargas de 30% (C30), 60% (C60) e placebo, utilizando um resistor de carga linear ( PowerBreathe Light ). O estudo hemodinâmico não invasivo foi realizado por bioimpedância cardiotorácica ( Niccomo™CardioScreen® ). Análise estatística foi feita com o Teste t de Student e a correlação de Pearson, considerado significante p≤0,05. Resultados Foi observado aumento da frequência cardíaca (FC) com a C30 (64±15 vs 69±15 bpm; p=0,005) e C60 (67±14 vs 73±14 bpm, p=0,002). No volume sistólico (VS), observou-se diminuição com a C30 (73±26 vs 64±20 ml; p=0,004). O débito cardíaco (DC) apresentou aumento apenas com a C60 (4,6±1,5 vs 5,3±1,7 l/min; p=-0,001). Conclusão Quando utilizada a carga de 60%, em uma sessão única de EI, foram observadas alterações na RHC. A FC e o DC aumentaram, assim como as escalas de Borg e sensação subjetiva de dispneia. Já a carga de 30% promoveu diminuição do VS. (Arq Bras Cardiol. 2020; 114(4):656-663)

Abstract Background Inspiratory muscle weakness contributes to exercise intolerance and decreased quality of life in patients with heart failure. Studies with inspiratory muscle training show improvement in inspiratory muscle strength, functional capacity and quality of life. However, little is known about the central hemodynamic response (CHR) during inspiratory exercise (IE). Objective To evaluate CHR in a single IE session with different loads (placebo, 30% and 60%) in heart failure. Methods Randomized placebo-controlled clinical trial in patients with heart failure with reduced ejection fraction, functional class II and III. Twenty patients aged 65 ± 11 years completed a single session of inspiratory exercise, in 3 cycles of 15 minutes, with a 1-hour washout, involving loads of 30% (C30), 60% (C60) and placebo, using a linear load resistor (PowerBreathe Light). The noninvasive hemodynamic study was performed by cardiothoracic bioimpedance (Niccomo™ CardioScreen®). Statistical analysis was performed with Student's t-test and Pearson's correlation, and P≤0.05 was considered significant. Results An increase in heart rate (HR) was observed with C30 (64 ± 15 vs 69 ± 15 bpm; p = 0.005) and C60 (67 ± 14 vs 73 ± 14 bpm, p = 0.002). A decrease was observed in systolic volume (SV) with C30 (73 ± 26 vs 64 ± 20 ml; p = 0.004). Cardiac output (CO), on its turn, increased only with C60 (4.6 ± 1.5 vs 5.3 ± 1.7 l/min; p = -0.001). Conclusion When using the 60% load, in a single IE session, changes in CHR were observed. HR and CD increased, as did the Borg scales and subjective sensation of dyspnea. The 30% load reduced the SV. (Arq Bras Cardiol. 2020; 114(4):656-663)

Danza terapéutica y ejercicio físico. efecto sobre la fibromialgia / Therapeutic dance and physical exercise. effect on fibromyalgia / Dança terapéutica e exercício físico. efeito sobre a fibromialgia

Resumen Objetivo: Establecer el efecto de la danza terapéutica y del ejercicio físico sobre la sintomatología y el número de puntos dolorosos en mujeres con fibromialgia. Materiales y métodos: Estudio cuasiexperimental que consideró una muestra probabilística aleatorizada. Un total de 37 mujeres con fibromialgia fueron sometidas a programas de danza terapéutica (n=18) y ejercicio físico (n=19). La edad promedio fue 47,4±8,4 años. La duración de la intervención fue de 3 meses con una frecuencia de entrenamiento de 2 sesiones por semana y una duración de 60 minutos por sesión. Todas las participantes suministraron información que permitió determinar el índice de dolor generalizado y la escala de severidad de síntomas. Resultados: La danza terapéutica y el ejercicio físico disminuyeron significativamente el número de puntos dolorosos (12,1±2,8 a 7,3±3,1 para valores pre y post respectivamente (p=0,000)); y los síntomas asociados a la fibromialgia (8,7±2,3 a 5,7±2,6 para valores pre y post respectivamente (p=0,000)). Conclusiones: La danza terapéutica y el ejercicio físico tienen un efecto benéfico equivalente en la disminución del índice de dolor generalizado, la depresión, los síntomas cognitivos y los trastornos del sueño en mujeres con fibromialgia.

Abstract Objective: To establish the effect of therapeutic dance and physical exercise on the symptomatology and number of painful points in women with fibromyalgia. Materials and methods: Quasi-experimental study that considered a randomized probabilistic sample. A total of 37 women with fibromyalgia underwent therapeutic dance (n=18) and physical exercise (n=19) programs. The average age was 47.4 ± 8.4 years. The length of the intervention was 3 months with a training frequency of 2 sessions per week and a duration of 60 minutes per session. All the participants provided information that allowed to determine the general pain index (GPI) and the scale of symptom severity (SSS). Results: Therapeutic dance and physical exercise significantly decreased the number of painful points (from 12.1 ± 2.8 to 7.3 ± 3.1 for pre- and post-values respectively (p = 0.000)) and the symptoms associated with fibromyalgia (8.7 ± 2.3 to 5.7 ± 2.6 for pre- and post-values respectively (p = 0.000)). Conclusions: Therapeutic dance and physical exercise have an equivalent beneficial effect on the reduction of the general pain index, depression, cognitive symptoms and sleep disorders in women with fibromyalgia.

Resumo Objetivo: Estabelecer o efeito da dança terapêutica e o exercício físico sobre a sintomatologia e o número de pontos dolorosos em mulheres com fibromialgia. Materiais e métodos: Estudo quase experimental que considerou uma amostra probabilística aleatória. Um total de 37 mulheres com fibromialgia foram submetidas a programas de dança terapêutica (n=18) e exercício físico (n=19). A idade média foi 47,4±8,4 anos. A duração da intervenção foi de 3 meses com uma frequência de treinamento de 2 sessões por semana e uma duração de 60 minutos por sessão. Todas as participantes subministraram informação que permitiu determinar o índice da dor generalizada e a escada de severidade de sintomas. Resultados: A dança terapêutica e o exercício físico diminuíram significativamente o número de pontos dolorosos (12,1±2,8 a 7,3±3,1 para valores pré e post respectivamente (p=0,000)); e os sintomas associados à fibromialgia (8,7±2,3 a 5,7±2,6 para valores pré e post respectivamente (p=0,000)). Conclusões: A dança terapêutica e o exercício físico tem um efeito benéfico equivalente na diminuição do índice da dor generalizado, a depressão, os sintomas cognitivos e os transtornos do sono em mulheres com fibromialgia.

Risk factors for postoperative fatigue syndrome in outpatients with painless gastroscopy / 中华麻醉学杂志

Objective@#To identify the risk factors for postoperative fatigue syndrome (POFS) in outpatients with painless gastroscopy.@*Methods@#The outpatients received painless gastroscopy from October 2016 to February 2017 in our hospital were included in this study.The possible factors related to POFS were summarized by reviewing the relevant literature.The questionnaires were completed by the methods such as preoperative interview, intraoperative recording, and telephone follow-up.POFS occurrence, score and outcomes were evaluated.The patients were divided into POFS group (groupⅠ) and non-POFS group (groupⅡ) according to whether POFS occurred.The risk factors of which P values were less than 0.05 would enter the multivariate logistic regression analysis to stratify the risk factors.@*Results@#Two hundred and forty-six patients completed this study.Sixty-nine cases developed POFS, and the incidence was 28.0%, the initial fatigue score was (5.2±2.4), and the duration of POFS was 3(9) h. The mean consumption of propofol (according to anesthesia time, mg/min) was an independent risk factor for POFS.@*Conclusion@#The mean consumption of propofol is an independent risk factor for POFS in outpatients with painless gastroscopy.

Risk factors for postoperative fatigue syndrome in out-patients with painless colonoscopy / 中华麻醉学杂志

Objective To identify the risk factors for postoperative fatigue syndrome (POFS) in out-patients with painless colonoscopy.Methods The out-patients received painless colonoscopy from October 2016 to February 2017 in Northern Jiangsu People's Hospital were selected.The possible factors related to POFS,such as general situation,present history and past history,intraoperative conditions,postoperative diagnosis,were summarized by reviewing the relevant literature.The questionnaires were completed by preoperative interview,filling in questionnaires by doctors during operation,interview before leaving the hospital,and follow-up phone calls.POFS occurrence and initial fatigue scale and duration were evaluated.The patients were divided into POFS group (group Ⅰ) and non-POFS group (group Ⅱ) according to whether POFS occurred.The risk factors of which P values were less than 0.05 would enter the multivariable logistic regression analysis to stratify the risk factors.Results Four hundred and forty-one patients were enrolled in this study,129 cases developed POFS,and the incidence was 29.2％.Using dezocine and higher percentage of change in heart rate were the risk factors for POFS,and male and appropriately prolonging the waiting time on the day of examination were the protective factors for POFS.Conclusion Using dezocine and higher percentage of change in heart rate are the risk factors for POFS,and male and appropriately prolonging the waiting time on the day of examination are the protective factors for POFS in outpatients with painless colonoscopy.

Risk factors for postoperative fatigue syndrome in outpatients with painless gastroscopy / 中华麻醉学杂志

Objective To identify the risk factors for postoperative fatigue syndrome(POFS)in outpatients with painless gastroscopy.Methods The outpatients received painless gastroscopy from October 2016 to February 2017 in our hospital were included in this study.The possible factors related to POFS were summarized by reviewing the relevant literature.The questionnaires were completed by the methods such as preoperative interview,intraoperative recording,and telephone follow-up.POFS occurrence,score and outcomes were evaluated.The patients were divided into POFS group(groupⅠ)and non-POFS group(groupⅡ)according to whether POFS occurred.The risk factors of which P values were less than 0.05 would enter the multivariate logistic regression analysis to stratify the risk factors.Results Two hundred and forty-six patients completed this study.Sixty-nine cases developed POFS,and the incidence was 28.0％,the initial fatigue score was(5.2±2.4),and the duration of POFS was 3(9)h.The mean con-sumption of propofol(according to anesthesia time,mg/min)was an independent risk factor for POFS.Conclusion The mean consumption of propofol is an independent risk factor for POFS in outpatients with painless gastroscopy.

Clinical observation of abdominal acupuncture for subhealth insomnia / 针灸推拿医学（英文版）

Objective:To assess the clinical efficacy of abdominal acupuncture for subhealth insomnia.Methods:Eighty-two cases of subhealth insomnia were randomly divided into an observation group (41 cases) and a control group (41 cases).The control group was treated with conventional acupuncture.The observation group was treated with Bo's abdominal acupuncture on the basis of conventional acupuncture.Six treatments constituted one treatment course.The measuring scale of traditional Chinese medicine syndrome for subhealth state (MSSSHS) and Pittsburgh sleep quality index (PSQI) scores were compared between the two groups after two courses,to estimate the efficacy of abdominal acupuncture for subhealth insomnia.Results:One case dropped out from the observation group,while 2 cases dropped out from the control group.The MSSSHS score and PSQI score both declined after the treatment in the two groups (all P＜0.05).The MSSSHS and PSQI scores in the observation group were significantly lower than those in the control group (both P＜0.05).Conclusion:The abdominal acupuncture is effective for subhealth insomnia,and it can enhance the effect of conventional acupuncture.

Clinical research of acupoint application combined traditional Chinese medicine foot bath for the treatment of chronic fatigue syndrome / 国际中医中药杂志

Objective To investigate the clinical application of acupoint sticking combined traditional Chinese medicine foot bath for the treatment of chronic fatigue syndrome (CFS). Methods According to the random table method, 91 CFS patients were divided into control group (n=45) and the research group (n=46). The patients in the control group were treated with western medicine and acupoint application, while the patients in the research group were treated with Chinese medicine foot bath on the basis of control group. Two groups of patients were treated for 30 consecutive days. The clinical total effective rate of two groups of patients after treatment was assessed. The Pittsburgh sleep quality index scale (PSQI), BELL's chronic fatigue syndrome integral table and fatigue rating scale (FS-14) were determined respectively before and after treatment, at the same time, the levels of serum interleukin IL-1β, IL-6, IL-2 and interferon IFN-λ were detected respectively before and after treatment. In addition, the adverse reactionincidence and recurrence rate of two groups of patients were observed Results The total effective rate of research group was 91.3% (42/46), whilethe total effective rate of control group was 71.1% (32/45). The difference between two groups was statistically significant(χ 2=6.106,P=0.014).After treatment,the PSQI(3.65 ±0.71 vs.4.77 ±0.62,t=-8.008),FS-14(6.16 ±1.52 vs.8.03 ± 1.43,t=-6.042),IL-1β(3.28 ± 0.63 pg/ml vs.(6.86 ± 1.14)pg/ml,t=-18.595)] and IL-6 (20.03 ± 5.79 pg/ml vs. 24.85 ± 6.88 pg/ml, t=-3.619) of research group were significantly lower than the control group (P<0.05), while the BELL's (66.71 ± 12.79 vs.50.62 ± 10.22,t=-6.621), IL-2 (32.96 ± 6.57 pg/ml vs.26.78 ± 6.01 pg/ml, t=4.679)and IFN-λ(36.27 ± 6.71 pg/ml vs.25.63 ± 5.89 pg/mL,t=8.032)of research group were significantly higher than the control group (P<0.05). No serious adverse reactions occurred during the treatment of both groups. The recurrence rate of control group was 25.0% (8/32), which was significantly higher than the research group of 7.1% (3/42) (χ2=4.576, P=0.032). Conclusions The clinical curative effect of acupoint sticking combined Chinese medicine foot bath on the treatment for CFS is significantly, which can significantly improve the patient's quality of sleep and fatigue index, at the same time improve the serum level of inflammatory factors.

Therapeutic Observation of Scalp Acupuncture plus Acupuncture at Jiaji Points (EX-B 2) for Chronic Fatigue Syndrome / 上海针灸杂志

Objective To observe the clinical efficacy of scalp acupuncture plus acupuncture at Jiaji points (EX-B 2) in treating chronic fatigue syndrome (CFS).Method Seventy CFS patients were randomized into a treatment group and a control group, 35 cases in each group. The treatment group was intervened by scalp acupuncture plus acupuncture at Jiaji points (EX-B 2), while the control group was by ordinary acupuncture. The Fatigue Scale (FS)-14 was observed before and after treatment, and the clinical efficacies were compared.Result The FS-14 scores were significantly changed after treatment in both groups (P<0.01). After treatment, the FS-14 score of the treatment group was significantly different from that of the control group (P<0.05). The total effective rate and recovery-markedly-effective rate were respectively 91.4% and 71.4% in the treatment group, versus 82.9% and 45.7% in the control group. There was a significant difference in comparing the recovery-markedly-effective rate between the two groups (P<0.05).Conclusion Scalp acupuncture plus acupuncture at Jiaji points (EX-B 2) is an effective method in treating CFS.

Therapeutic Observation of Genger-partitioned Moxibustion plus Ba Zhen Decoction for Chronic Fatigue Syndrome / 上海针灸杂志

ObjectiveTo observe the therapeutic efficacy of ginger-partitioned moxibustion plus Ba Zhen decoction in treating chronic fatigue syndrome (CFS).MethodSixty patients with CFS were randomized into two groups, 30 in each group. The treatment group was intervened by ginger-partitioned moxibustion plus Ba Zhen decoction, while the control group was by electroacupuncture.ResultAfter 3 treatment courses, the total effective rate was 93.3% in the treatment group versus 83.3% in the control group, and the difference was statistically significant (P<0.05).ConclusionGinger-partitioned moxibustion plus Ba Zhen decoction can produce a higher total effective rate than electroacupuncture in treating CFS.

Study of the Clinical Effect of Movable Cupping on Sub-health Body / 上海针灸杂志

Objective To investigate the intervening effect of movable cupping on sub-health status. Methods Movable cupping was performed on bilateral bladder meridians and the Du meridian in 12 patients with sub-health status. The sub-health status rating scale score, the visual analogue pain intensity scale score, hemorheological parameters and immunoglobulins were observed before and after movable cupping.Results The sub-health status rating scale score, the visual analogue pain intensity scale score, whole blood viscosity 200 and plasma viscosity decreased after treatment compared with before in the patients, and there were statistically significant differences (P0.05). Conclusion Movable cupping has clinically a certain improving effect on bodily sub-health status.

Influence of specific acupoints moxibustion of Yizhichan on quality of sleep, ability to reaction of patinets with chronic fatigue syndrome / 国际中医中药杂志

Objective To study the effects of Yizhichan moxibustion on chronic fatigue syndrome (CFS) athletes.Methods 143 patients of CFS were blind randomly devided into3 groups, which were moxibustion of Yizhichan (56 cases) group, general moxibustion group (42 cases), and normal group (45 cases).The normal group was treated by passive massage for relaxation, the moxibustion of Yizhichan group was treated by specific acupoints application of moxibustion of Yizhichan in addition to passive massage;and the general moxibustion groupwas treated by general moxibustion in addition to passive massage.All sample were treated once a day for 6 days in a week.3 weeks was a period of treatment, and the total time of treatment was 15 weeks.Results After treatment, the sleep quality (1.73 ± 0.73, 1.54 ± 0.85 vs.0.83 ± 0.52, F=14.130), time for sleep (1.57 ± 0.60, 1.35 ± 0.60 vs.1.03 ± 0.54, F=5.386), sleep time (1.78 ± 0.71, 1.77 ± 0.61 vs.0.67 ± 0.65, F=19.811), daytime dysfunction (0.78 ± 0.83, 1.64 ± 0.83 vs.1.03 ± 0.83, F=4.798) in the control group, moxibustion of Yizhichan group and a general moxibustion group were statistically significant(P＜0.05).The total effective rate of the moxibustion of Yizhichan group was better than the control group and the general moxibustion group (83.8％, 42.2％ vs.63.6％;x2=13.973, P=0.001).Conclusion Specific acupoints moxibustion of Yizhichan is a beneficial exploration of moxibustion methods of traditional Chinese medicine, and can improve CFS athletes level of physical health, attention and sleep quality.

Treatment of 22 Cases of Chronic Fatigue Syndrome by Puncturing Back-Shu Points / 针灸推拿医学（英文版）

Objective: To observe the clinical effect of puncturing Back-Shu points in treating chronic fatigue syndrome. Methods: Twenty-two subjects were recruited and treated by puncturing corresponding Back-Shu points based on syndrome differentiation. The short-form General Health Survey (MOSSF GHS) and the Chalder Questionnaires for Fatigue were adopted for evaluating the therapeutic effects. Results: Of the 22 patients, 4 cases showed a marked effect, 11 got effect, 7 got failure, and the total effective rate was 68.2%. Conclusion: Puncturing Back-Shu points is effective in relieving the symptoms of chronic fatigue syndrome and enhancing the patients' health standard.

Tuina Intervention and Sleep and Emotional Disorders due to Chronic Fatigue Syndrome / 针灸推拿医学（英文版）

Objective:To study the tuina effect on sleep disorder and emotional problems of chronic fatigue syndrome (CFS) cases.Method:Thirty CFS cases were treated in the treatment group,by applying one-thumb pushing,rolling and pressing-kneading manipulations along the Governor Vessel,Bladder and Yangming Meridians.The intended major points include Fengfu (GV 16),Yaoyangguan (GV 3),Xinshu (BL 15),Pishu (BL 20),Ganshu (BL 18),Hegu (LI 4) and Taixi (KI 3).The treatment was done once every other day;10 times constitute a course of treatment.Another 30 healthy cases were selected in the control group,without any intervention.The sleep quality and mental state in the two groups were evaluated by PSQI,HAMA and HAMD.In addition,the pre-treatment and post-treatment score changes were observed.Results:Before treatment,the total score of PSQI,sleep quality,time of falling asleep,sleep efficiency,sleep disorder,daytime functional impairment,and scores of HAMD and HAMA in treatment group were all substantially higher than the control group (P＜0.01).After 10 tuina treatments,the total score of PSQI,time of falling asleep,sleep disorder and daytime functional impairment as well as scores of HAMD and HAMA in treatment group were significantly changed,compared with before treatment,P＜0.05.Conclusion:Those with CFS may present with sleep disorder and mental or psychological abnormality,tuina can improve their sleep quality and adjust their mental conditions.

The levels of transforming growth factor-β1 mRNA and estrogen receptor βwt mRNA expression on peripheral blood monocytes of patients with chronic fatigue syndrome / 中华检验医学杂志

Objective To detect the expression of TGF-β1 mRNA and ERβwt mRNA in peripheral blood monoanclear cells (PBMCs) in patients with chronic fatigue syndrome (CFS), and their relationship with pathogenesis of CFS. Methods Fluorescence quantitative RT-PCR (FQ-RT-PCR) was used to examine TGF-β1 mRNA and ERβwt mRNA expression of peripheral blood monocytes in 63 cases with CFS,50 cases with other diseases, and 50 healthy controls. The gene expression levels were calculated with the formula △Ct=Ct(target gene) - Ct(internal control). Results The mean TGF-β1 mRNA expression of CFS patients (△Ct = 3.27 ± 0. 58) was higher than that of disease controls (△Ct = 4. 54 ± 1.05, t = 8. 11, P <0.01) and that of healthy controls (△Ct = 4. 37 ± 1.00, t = 7. 02, P < 0. 01). The mean ERβwt mRNA expression of CFS patients (△Ct =9. 34 ±0. 92) was lower than that of disease controls(△Ct =7.12±0. 47, t = 15.44 ,P < 0. 01) and that of healthy controls(△Ct = 7. 10 ±0. 48, t = 15.47, P < 0. 01). Conclusions The TGF-β1 mRNA and ER βwt mRNA expression levels of PBMCs are siguificantly elevated in patients with CFS. It may be implicated in the pathogenesis of CSF.

Treatment of Fatigue Syndrome by Tuina: A Report of 79 Cases / 针灸推拿医学（英文版）

Purpose To study the therapeutic methods of fatigue syndrome. Methods Seventy-nine cases of fatigue syndrome were treated by Tuina manipulation and a comprehensive assessment of main complaints and accompanied symptoms was made. Results After 3month's Tuina treatment, 21 cases were cured, 43 cases improved, 15 cases obtained no effects. Conclusion Tuina has a unique therapeutic effect on fatigue syndrome.